Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2)

Am J Surg Pathol. 2000 Jul;24(7):1020-6. doi: 10.1097/00000478-200007000-00015.

Abstract

A case of extraskeletal myxoid chondrosarcoma (EMC) in which there was histochemical, immunohistochemical, and ultrastructural evidence of neuroendocrine differentiation is reported. Genetic investigations showed the recently described novel translocation t(9;17)(q22;q11.2) and associated fusion of the CHN and RBP56 genes, contrasting with the translocation t(9;22)(q22;q12) and EWS/CHN gene fusion found in the majority of EMCs.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Buttocks
  • Cell Differentiation
  • Chondrosarcoma / genetics
  • Chondrosarcoma / metabolism
  • Chondrosarcoma / pathology*
  • Chromosomes, Human, Pair 17 / genetics*
  • Chromosomes, Human, Pair 9 / genetics*
  • Cytogenetics
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Male
  • Middle Aged
  • Neurosecretory Systems / metabolism
  • Neurosecretory Systems / pathology*
  • Procollagen / genetics
  • Procollagen / metabolism
  • RNA, Messenger / analysis
  • RNA, Neoplasm / genetics
  • Silver Staining
  • Soft Tissue Neoplasms / genetics
  • Soft Tissue Neoplasms / metabolism
  • Soft Tissue Neoplasms / pathology*
  • Translocation, Genetic*

Substances

  • Biomarkers, Tumor
  • Procollagen
  • RNA, Messenger
  • RNA, Neoplasm