Abstract
We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 [Allikmets et al. (1995) Mamm. Genome 6, 111-117]. The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non-expressed pseudogene also exists at chromosome 15q13-14. The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / chemistry
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ATP-Binding Cassette Transporters / genetics*
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ATP-Binding Cassette Transporters / metabolism*
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Amino Acid Motifs
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Amino Acid Sequence
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Animals
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Bone Marrow / metabolism
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Cell Line
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Chromosomes, Human, Pair 1 / genetics
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Chromosomes, Human, Pair 15 / genetics
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Cloning, Molecular
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Gene Expression Profiling
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Humans
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In Situ Hybridization, Fluorescence
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Intracellular Membranes / chemistry
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Mitochondria / chemistry*
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Molecular Sequence Data
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Phylogeny
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Physical Chromosome Mapping
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Protein Sorting Signals / genetics
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Pseudogenes / genetics
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Sequence Alignment
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Transfection
Substances
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ABCB10 protein, human
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ATP-Binding Cassette Transporters
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Protein Sorting Signals
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RNA, Messenger
Associated data
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GENBANK/AF218417
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GENBANK/AF218418
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GENBANK/AF218419