Abstract
The pathogenesis of AIDS-associated myelopathy is unknown. Elevated HIV-1 viral load in CSF has been associated with cognitive impairment. The authors investigated if a similar association exists in patients with myelopathy. The authors evaluated levels of HIV-1 RNA in the CSF of 16 individuals with AIDS myelopathy and in 16 nonmyelopathic HIV-infected control subjects. There was no correlation between levels of HIV-1 RNA and the presence or severity of myelopathy.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / cerebrospinal fluid*
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Acquired Immunodeficiency Syndrome / virology
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Adult
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Female
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HIV-1 / genetics
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HIV-1 / isolation & purification*
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Humans
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Male
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Middle Aged
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RNA, Viral / cerebrospinal fluid
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Severity of Illness Index
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Spinal Cord Diseases / cerebrospinal fluid*
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Spinal Cord Diseases / virology*
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Tumor Necrosis Factor-alpha / cerebrospinal fluid
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Viral Load*
Substances
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RNA, Viral
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Tumor Necrosis Factor-alpha