Abstract
Quantitative expression of neutrophil CD11b/CD18 following chemotherapy (either conventional dose consolidation chemotherapy or high dose chemotherapy with autologous stem cell transplantation) was investigated during the early recovery phase (neutrophil count 0. 5-1.0x109/l) and at full recovery (neutrophil count 1.0-2.5x109/l) following treatment. CD11b/18 expression was normal in stem cell transplantation supported patients during both early and full neutrophil recovery. By contrast CD11b/CD18 expression was markedly decreased in patients who received chemotherapy without stem cell support. These results suggest that recovery of neutrophil count may not always coincide with recovery of neutrophil function and that G-CSF stimulated peripheral stem cell transplantation enhances neutrophil function post chemotherapy.
MeSH terms
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Acute Disease
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Adolescent
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Biomarkers
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Breast Neoplasms / blood
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Breast Neoplasms / drug therapy
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Breast Neoplasms / therapy
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CD18 Antigens / biosynthesis*
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CD18 Antigens / genetics
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Combined Modality Therapy
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Cytarabine / administration & dosage
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Cytarabine / adverse effects
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Etoposide / administration & dosage
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Etoposide / adverse effects
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Female
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Filgrastim
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Gene Expression Regulation, Leukemic*
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Granulocyte Colony-Stimulating Factor / therapeutic use
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Hematopoietic Stem Cell Transplantation*
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Humans
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Leukemia, Myeloid / drug therapy*
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Leukemia, Myeloid / genetics
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Leukemia, Myeloid / metabolism
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Leukemia, Myeloid / therapy
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Macrophage-1 Antigen / biosynthesis*
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Macrophage-1 Antigen / genetics
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Male
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Melphalan / administration & dosage
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Melphalan / adverse effects
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Middle Aged
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Neutropenia / chemically induced
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Neutropenia / metabolism*
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Neutropenia / therapy
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Recombinant Proteins
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Remission Induction
Substances
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Biomarkers
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CD18 Antigens
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Macrophage-1 Antigen
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Neoplasm Proteins
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Recombinant Proteins
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Cytarabine
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Granulocyte Colony-Stimulating Factor
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Etoposide
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Filgrastim
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Melphalan