Abstract
The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on to develop a highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ hybridization (FISH) and the MLL/AF4 rearrangement by reverse transcriptase-polymerase chain reaction (RT-PCR).
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Blotting, Southern
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Chromosomes, Human, Pair 11 / genetics*
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Chromosomes, Human, Pair 8 / genetics*
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Chromosomes, Human, Pair 9 / genetics*
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Cytogenetic Analysis
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DNA, Neoplasm / genetics
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DNA-Binding Proteins / genetics
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Histone-Lysine N-Methyltransferase
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Humans
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In Situ Hybridization, Fluorescence
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Karyotyping
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Leukemia, Monocytic, Acute / genetics*
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Leukemia, Monocytic, Acute / pathology
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Male
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Myeloid-Lymphoid Leukemia Protein
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Nuclear Proteins / genetics
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Oncogene Proteins, Fusion / genetics
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Pancytopenia / genetics
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Pancytopenia / pathology*
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Proto-Oncogenes*
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Transcription Factors*
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Translocation, Genetic
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Trisomy*
Substances
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DNA, Neoplasm
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DNA-Binding Proteins
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KMT2A protein, human
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MLLT3 protein, human
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Nuclear Proteins
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Oncogene Proteins, Fusion
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Transcription Factors
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Myeloid-Lymphoid Leukemia Protein
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Histone-Lysine N-Methyltransferase