Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer

Br J Cancer. 2000 Oct;83(7):870-3. doi: 10.1054/bjoc.2000.1395.

Abstract

Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility (P< 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours (P = 0.03). In summary, the upregulation of fascin in HR-negative breast cancers may contribute to their more aggressive behaviour.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actins / metabolism
  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Carrier Proteins / biosynthesis*
  • Carrier Proteins / genetics
  • Cell Movement / physiology
  • Female
  • Flow Cytometry
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Microfilament Proteins / biosynthesis*
  • Microfilament Proteins / genetics
  • Middle Aged
  • Neoplasm Invasiveness
  • Receptors, Estrogen / physiology*
  • Receptors, Progesterone / physiology*
  • Up-Regulation

Substances

  • Actins
  • Carrier Proteins
  • Microfilament Proteins
  • Receptors, Estrogen
  • Receptors, Progesterone
  • fascin