Abstract
Research stemming from interests in neuronal-glial interactions has led to the identification of a number of novel trophic factors, such as the dopaminergic neurotrophic factor glial cell line-derived neurotrophic factor (GDNF). Delivery of the GDNF gene to rat models of Parkinson's disease suggests a potential clinical use of GDNF gene therapy for humans with this disease. This review article briefly summarizes the history of GDNF and the effects of GDNF gene delivery prior to or after a lesion of the rat nigrostriatal system.
MeSH terms
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Animals
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Glial Cell Line-Derived Neurotrophic Factor
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Humans
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Nerve Growth Factors / genetics
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Nerve Growth Factors / metabolism
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Nerve Growth Factors / physiology*
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Nerve Tissue Proteins / physiology*
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Neurodegenerative Diseases / genetics
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / physiopathology*
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Neuroglia / physiology*
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Neurons / physiology*
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Parkinson Disease, Secondary / genetics
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Rats
Substances
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GDNF protein, human
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Gdnf protein, rat
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Glial Cell Line-Derived Neurotrophic Factor
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Nerve Growth Factors
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Nerve Tissue Proteins