Abstract
In the mouse, resistance and susceptibility to intracellular growth of mycobacteria in macrophages is controlled by the Bcg (Nramp1) gene, which has been cloned and shown to encode a macrophage phagosomal membrane protein with a putative transporter function. In the homologous human NRAMP1 gene, a total of 11 polymorphisms have been identified, which are being used to test for the linkage of NRAMP1 alleles with human responses to mycobacteria, including susceptibility to tuberculosis and leprosy, as well as BCG immunotherapy in bladder cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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BCG Vaccine / therapeutic use*
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Carrier Proteins / genetics*
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Carrier Proteins / physiology
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Cation Transport Proteins*
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Genetic Linkage
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Genetic Markers
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Genetic Predisposition to Disease
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Humans
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Immunity, Innate / genetics
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Leprosy / genetics*
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Leprosy / immunology
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Membrane Proteins / genetics*
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Membrane Proteins / physiology
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Mice
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Tuberculosis, Pulmonary / genetics*
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Tuberculosis, Pulmonary / immunology
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Urinary Bladder Neoplasms / genetics
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Urinary Bladder Neoplasms / immunology
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Urinary Bladder Neoplasms / therapy*
Substances
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BCG Vaccine
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Carrier Proteins
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Cation Transport Proteins
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Genetic Markers
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Membrane Proteins
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natural resistance-associated macrophage protein 1