Allele NAT2*5 determines resistance to bronchial asthma in children

S I Makarova; V A Vavilin; V V Lyakhovich; S M Gavalov

doi:10.1007/BF02434881

Allele NAT2*5 determines resistance to bronchial asthma in children

Bull Exp Biol Med. 2000 Jun;129(6):575-7. doi: 10.1007/BF02434881.

Authors

S I Makarova¹, V A Vavilin, V V Lyakhovich, S M Gavalov

Affiliation

¹ Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. imbb@cyber.ma.nsc.ru

PMID: 11022254
DOI: 10.1007/BF02434881

Abstract

NAT2*5 allele was found in 54.8% healthy children and 35.9% children with bronchial asthma, i.e. the risk of bronchial asthma was considerably lower in individuals carrying NAT2*5 allele. NAT2*5 allele manifests itself in both homo- and heterozygous states.

MeSH terms

Adolescent
Arylamine N-Acetyltransferase / genetics*
Asthma / etiology
Asthma / genetics*
Child
Child, Preschool
Female
Genetic Predisposition to Disease*
Genotype
Humans
Male
Mutation / genetics
Odds Ratio
Polymorphism, Genetic
Tobacco Smoke Pollution

Substances

Tobacco Smoke Pollution
Arylamine N-Acetyltransferase
NAT2 protein, human