Abstract
Because amphetamine releases two to three times more dopamine in schizophrenia patients than in control subjects, and because calcium-calmodulin-dependent protein kinase II has a key role in the enhanced action of amphetamine-induced dopamine release in rats, the synaptic content of calcium-calmodulin-dependent protein kinase IIbeta mRNA was measured (by quantitative competitive RT-PCR; reverse transcriptase-polymerase chain reaction) in seven frontal cerebral cortices of post-mortem brains from patients who had schizophrenia and in seven control tissues. The results indicate that the mRNA of this kinase is elevated in the schizophrenia frontal cortex.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adult
-
Aged
-
Aged, 80 and over
-
Base Sequence
-
Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
-
Cyclic AMP-Dependent Protein Kinases / genetics*
-
Female
-
Frontal Lobe / metabolism*
-
Gene Expression Regulation, Enzymologic*
-
Humans
-
Male
-
Molecular Sequence Data
-
RNA, Messenger / genetics
-
Reference Values
-
Reverse Transcriptase Polymerase Chain Reaction
-
Schizophrenia / enzymology*
-
Schizophrenia / genetics*
-
Transcription, Genetic*
Substances
-
Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
-
PRKAR2B protein, human
-
RNA, Messenger
-
Cyclic AMP-Dependent Protein Kinases