Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract

D J Fowler; K H Nicolaides; J P Miell

doi:10.1093/humupd/6.5.495

Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract

Hum Reprod Update. 2000 Sep-Oct;6(5):495-504. doi: 10.1093/humupd/6.5.495.

Authors

D J Fowler¹, K H Nicolaides, J P Miell

Affiliation

¹ Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College Hospital, London UK. djfowler@partners.org

PMID: 11045880
DOI: 10.1093/humupd/6.5.495

Abstract

Insulin-like growth factor-1 (IGFBP-1) is particularly important in human female reproductive physiology, where it is involved with other factors in a complex system which regulates menstrual cycles, puberty, ovulation, decidualization, implantation and fetal growth. This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGFBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Embryo Implantation / physiology
Embryonic and Fetal Development
Endometrium / physiology
Female
Genitalia, Female / physiology*
Humans
Insulin-Like Growth Factor Binding Protein 1 / genetics
Insulin-Like Growth Factor Binding Protein 1 / physiology*
Ovary / pathology
Ovary / physiology
Polycystic Ovary Syndrome / physiopathology
Pregnancy
Reproduction / genetics
Reproduction / physiology*
Somatomedins / physiology

Substances

Insulin-Like Growth Factor Binding Protein 1
Somatomedins