Abstract
Inversion 16(p13q22) is most commonly associated with acute myelomonocytic leukemia with abnormal eosinophils (M4). In association with this inversion, a proximal deletion at the 16p13 primary arm breakpoint occurs in 20% of cases. We report on a first case of inversion 16 with a distal deletion at the primary arm breakpoint 16q22, detected by using the fluorescent-labeled dual-color probe CBFB.
MeSH terms
-
Child, Preschool
-
Chromosome Inversion*
-
Chromosomes, Human, Pair 16*
-
Core Binding Factor beta Subunit
-
DNA-Binding Proteins / genetics*
-
Gene Deletion*
-
Humans
-
In Situ Hybridization, Fluorescence
-
Karyotyping
-
Leukemia, Myelomonocytic, Acute / genetics*
-
Male
-
Transcription Factor AP-2
-
Transcription Factors / genetics*
Substances
-
CBFB protein, human
-
Core Binding Factor beta Subunit
-
DNA-Binding Proteins
-
Transcription Factor AP-2
-
Transcription Factors