Deletion of 3'-CBFB gene in association with an inversion (16)(p13q22) and a loss of the Y chromosome in a 2-year-Old child with acute myelogenous leukemia-M4

Cancer Genet Cytogenet. 2000 Sep;121(2):216-9. doi: 10.1016/s0165-4608(00)00251-x.

Abstract

Inversion 16(p13q22) is most commonly associated with acute myelomonocytic leukemia with abnormal eosinophils (M4). In association with this inversion, a proximal deletion at the 16p13 primary arm breakpoint occurs in 20% of cases. We report on a first case of inversion 16 with a distal deletion at the primary arm breakpoint 16q22, detected by using the fluorescent-labeled dual-color probe CBFB.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Chromosome Inversion*
  • Chromosomes, Human, Pair 16*
  • Core Binding Factor beta Subunit
  • DNA-Binding Proteins / genetics*
  • Gene Deletion*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Myelomonocytic, Acute / genetics*
  • Male
  • Transcription Factor AP-2
  • Transcription Factors / genetics*

Substances

  • CBFB protein, human
  • Core Binding Factor beta Subunit
  • DNA-Binding Proteins
  • Transcription Factor AP-2
  • Transcription Factors