The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins

G R Uhl; S Li; N Takahashi; K Itokawa; Z Lin; M Hazama; I Sora

doi:10.1096/fj.00-0205rev

The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins

FASEB J. 2000 Dec;14(15):2459-65. doi: 10.1096/fj.00-0205rev.

Authors

G R Uhl¹, S Li, N Takahashi, K Itokawa, Z Lin, M Hazama, I Sora

Affiliation

¹ Molecular Neurobiology Branch, NIDA-IRP, National Institutes of Health, Baltimore, Maryland 21224, USA. guhl@intra.nida.nih.gov

PMID: 11099463
DOI: 10.1096/fj.00-0205rev

Abstract

Monoamine compartmentalization in monoaminergic neurons uses serial action of the plasma membrane and vesicular monoamine (VAMT2) transporters. We can now define the sequences of the genes encoding these transporters in mice and humans, examine influences of deletions of this gene and alteration in its expression levels in transgenic mice, and identify sequence polymorphisms in the human VMAT2 gene. Examination of VMAT2 variants can provide potential insights into roles for allelic variants at these loci in variant drug responses and in diseases linked to monoaminergic systems, including substance abuse and Parkinson's disease.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Aging / genetics
Amphetamines / pharmacology
Animals
Arrhythmias, Cardiac / genetics
Humans
MPTP Poisoning / genetics
Membrane Glycoproteins / genetics*
Membrane Transport Proteins*
Mice
Neuropeptides*
Polymorphism, Genetic
Rats
Vesicular Biogenic Amine Transport Proteins
Vesicular Monoamine Transport Proteins

Substances

Amphetamines
Membrane Glycoproteins
Membrane Transport Proteins
Neuropeptides
SLC18A2 protein, human
Slc18a2 protein, mouse
Slc18a2 protein, rat
Vesicular Biogenic Amine Transport Proteins
Vesicular Monoamine Transport Proteins