Follicular lymphoma with trisomy 18 and over-expression of BCL2 in the absence of t(14;18)(q32;q21)

Cancer Genet Cytogenet. 2000 Nov;123(1):52-4. doi: 10.1016/s0165-4608(00)00301-0.

Abstract

A 66-year-old female who presented with cervical lymphadenopathy and splenomegaly was found to have large B-cell lymphoma on lymph node biopsy. However, trephine biopsy revealed involvement of the marrow by follicular lymphoma, and cytogenetic study showed an abnormal clone with 47,XX,+18.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chromosomes, Human, Pair 14 / genetics
  • Chromosomes, Human, Pair 18 / genetics*
  • Female
  • Humans
  • Immunohistochemistry
  • Karyotyping
  • Lymphoma, Follicular / genetics*
  • Lymphoma, Follicular / pathology
  • Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
  • Translocation, Genetic
  • Trisomy*
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / pathology

Substances

  • Proto-Oncogene Proteins c-bcl-2