Abstract
Hepatoblastoma, a rare pediatric liver tumour, is a poorly understood disease. While expression studies for some members of the Insulin-like growth factor axis have been studied in hepatoblastoma, a systematic analysis of the IGF-axis has not been carried out. We have examined a series of hepatoblastomas with matched normal liver tissue for gene expression differences with emphasis on members of the insulin-like growth factor binding proteins. The expression profiles obtained reveal that the expression of these genes are altered in these tumors. The results indicate that the IGF-axis is seriously disturbed in the tumors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Carrier Proteins / biosynthesis
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Carrier Proteins / genetics
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Child
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Child, Preschool
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Female
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic
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Glycoproteins / biosynthesis
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Glycoproteins / genetics
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Hepatoblastoma / genetics
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Hepatoblastoma / metabolism*
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Humans
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Insulin-Like Growth Factor Binding Proteins / biosynthesis*
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Insulin-Like Growth Factor Binding Proteins / genetics
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Liver Neoplasms / genetics
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Liver Neoplasms / metabolism*
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Male
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Middle Aged
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Protein Isoforms
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA, Neoplasm / genetics
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RNA, Neoplasm / isolation & purification
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RNA, Neoplasm / metabolism
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Receptor, Insulin / biosynthesis*
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Receptor, Insulin / genetics
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Ribonucleases / metabolism
Substances
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Carrier Proteins
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Glycoproteins
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Insulin-Like Growth Factor Binding Proteins
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Protein Isoforms
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RNA, Messenger
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RNA, Neoplasm
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insulin-like growth factor binding protein, acid labile subunit
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Receptor, Insulin
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Ribonucleases