Impact of human papillomavirus infection on the expression of the KAI1 metastasis suppressor protein in invasive cervical cancer

Cancer Lett. 2001 Jan 26;162(2):261-6. doi: 10.1016/s0304-3835(00)00672-8.

Abstract

Downregulation of KAI1 metastasis suppressor protein is associated with dismal prognosis in a variety of cancers. Mutation of p53 was suggested to be involved in KAI1-downregulation. In cervical cancer, p53 is inactivated by human papillomavirus (HPV) oncoprotein E6 with the grade of inactivation depending on the HPV type. KAI1-expression was immunohistochemically determined in 67 specimens of cervical cancer, HPV-typing was performed using polymerase chain reaction (PCR), cloning, and sequencing. KAI1-downregulation was found in 68.1% of patients, HPV-infection in 91%. There was no association of KAI1-downregulation and infection with a particular HPV type. KAI1-downregulation in cervical cancer seems independent of HPV-E6 induced p53 inactivation.

Publication types

  • Comparative Study

MeSH terms

  • Antigens, CD / biosynthesis*
  • Antigens, CD / genetics
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / virology*
  • Down-Regulation
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunohistochemistry
  • Kangai-1 Protein
  • Membrane Glycoproteins / biosynthesis*
  • Membrane Glycoproteins / genetics
  • Middle Aged
  • Papillomaviridae* / classification
  • Papillomavirus Infections / metabolism*
  • Papillomavirus Infections / virology
  • Proto-Oncogene Proteins*
  • Tumor Virus Infections / metabolism*
  • Tumor Virus Infections / virology
  • Uterine Cervical Neoplasms / genetics
  • Uterine Cervical Neoplasms / metabolism*
  • Uterine Cervical Neoplasms / virology*

Substances

  • Antigens, CD
  • CD82 protein, human
  • Kangai-1 Protein
  • Membrane Glycoproteins
  • Proto-Oncogene Proteins