Despite advances in treatment and diagnosis, postoperative endophthalmitis (POE) is still not an entirely manageable complication after cataract surgery. This review focuses on recent developments regarding epidemiology, diagnosis based on the polymerase chain reaction method, experimental antibiotic therapy and clinical experience with intravitreal steroids, and experimental findings of the inflammatory process of POE, all of which are areas that may contribute to a broader understanding of POE.