Abstract
Jejunal biopsies from volunteers challenged with Cryptosporidium parvum were examined for tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1 beta mRNA. Postchallenge biopsies from 15 of 28 (54%) volunteers expressed TNF-alpha; 14% expressed IL-1 beta. Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-alpha and IL-1 beta are not key mediators of diarrhea in human cryptosporidiosis.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Biopsy
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Cryptosporidiosis / immunology*
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Cryptosporidium parvum*
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Diarrhea / etiology*
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Humans
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Interleukin-1 / biosynthesis*
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Interleukin-1 / genetics
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Interleukin-15 / biosynthesis
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Jejunum / metabolism*
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RNA, Messenger / analysis
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Tumor Necrosis Factor-alpha / biosynthesis*
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Tumor Necrosis Factor-alpha / genetics
Substances
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Interleukin-1
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Interleukin-15
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RNA, Messenger
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Tumor Necrosis Factor-alpha