Soundbites

Nat Genet. 2001 Feb;27(2):129-30. doi: 10.1038/84728.

Abstract

Dentinogenesis imperfecta (DGI) is characterized by discolored teeth with an opalescent sheen and dentin that fails to support enamel, causing it to easily chip. Two new studies show that DGI is associated with mutations in DSPP, a gene encoding dentin sialophosphoprotein that is processed into two proteins: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). These are key components of the dentin extracellular matrix (DECM). Notably, missense mutations in DSPP are also associated with progressive hearing loss.

Publication types

  • Comment

MeSH terms

  • Deafness / genetics*
  • Dentinogenesis Imperfecta / etiology
  • Dentinogenesis Imperfecta / genetics*
  • Extracellular Matrix Proteins
  • Humans
  • Odontogenesis / genetics
  • Phosphoproteins / genetics*
  • Phosphoproteins / metabolism
  • Protein Precursors / genetics*
  • Protein Precursors / metabolism
  • Protein Processing, Post-Translational
  • Sialoglycoproteins / genetics*
  • Sialoglycoproteins / metabolism

Substances

  • Extracellular Matrix Proteins
  • Phosphoproteins
  • Protein Precursors
  • Sialoglycoproteins
  • dentin sialophosphoprotein
  • phosphophoryn