Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis

H Takayama; Y Nagashima; M Hara; H Takagi; M Mori; G Merlino; Y Nakazato

doi:10.1067/mjd.2001.112403

Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis

J Am Acad Dermatol. 2001 Mar;44(3):538-40. doi: 10.1067/mjd.2001.112403.

Authors

H Takayama¹, Y Nagashima, M Hara, H Takagi, M Mori, G Merlino, Y Nakazato

Affiliation

¹ First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan. hitakaya@showa.gunma-u.ac.jp

PMID: 11209133
DOI: 10.1067/mjd.2001.112403

Abstract

Transgenic mice overexpressing hepatocyte growth factor/scatter factor (HGF/SF) demonstrate extensive pigmented nevi in both skin and leptomeninges of the central nervous system resembling human neurocutaneous melanosis. We immunohistochemically detected HGF/SF receptor, Met, in a congenital nevus of an infant with neurocutaneous melanosis, indicating that deregulation of HGF/SF-Met signaling in the critical period of development may lead to this fatal syndrome.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Child, Preschool
Humans
Immunohistochemistry
Male
Melanosis / genetics*
Melanosis / immunology
Mice
Neurocutaneous Syndromes / genetics*
Neurocutaneous Syndromes / immunology
Nevus, Pigmented / congenital*
Nevus, Pigmented / immunology
Nevus, Pigmented / pathology
Proto-Oncogene Mas
Proto-Oncogene Proteins c-met / analysis*
Proto-Oncogene Proteins c-met / immunology
Signal Transduction

Substances

MAS1 protein, human
Proto-Oncogene Mas
Proto-Oncogene Proteins c-met