ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3254-7. doi: 10.1073/pnas.051484398.

Abstract

DPC4 is known to mediate signals initiated by type beta transforming growth factor (TGFbeta) as well as by other TGFbeta superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFbeta receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Activin Receptors, Type I / genetics*
  • Adenocarcinoma / genetics*
  • DNA-Binding Proteins / genetics
  • Genes, Reporter
  • Humans
  • Mutation*
  • Pancreatic Neoplasms / genetics*
  • Proteins*
  • Smad4 Protein
  • Trans-Activators / genetics
  • Transcriptional Activation
  • Tumor Cells, Cultured

Substances

  • DNA-Binding Proteins
  • Proteins
  • SMAD4 protein, human
  • Smad4 Protein
  • Trans-Activators
  • ACVR1B protein, human
  • Activin Receptors, Type I