Androgen-producing, atypically proliferating endometrioid tumor arising in endometriosis

J L Powell; G P Connor; G S Henderson

Androgen-producing, atypically proliferating endometrioid tumor arising in endometriosis

South Med J. 2001 Apr;94(4):450-3.

Authors

J L Powell¹, G P Connor, G S Henderson

Affiliation

¹ Department of Obstetrics and Gynecology, New Hanover Regional Medical Center, Wilmington, NC, USA.

PMID: 11332919

Abstract

A case of androgen-secreting borderline endometrioid tumor arising in endometriosis of the rectovaginal septum is presented. It occurred 10 years after total abdominal hysterectomy and bilateral salpingo-oophorectomy for extensive endometriosis of the fallopian tubes and ovaries, adenomyosis, and leiomyomas of the uterus. We believe 7 years of unopposed continuous oral estrogen replacement therapy contributed to the malignant transformation of the endometriosis.

Publication types

Case Reports

MeSH terms

Abdominal Pain / etiology
Androgens / metabolism*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carcinoma, Endometrioid / complications*
Carcinoma, Endometrioid / pathology*
Cell Transformation, Neoplastic / drug effects
Combined Modality Therapy
Dyspareunia / etiology
Endometriosis / complications*
Endometriosis / surgery
Estrogen Replacement Therapy / adverse effects
Estrogen Replacement Therapy / methods
Female
Hirsutism / etiology
Humans
Hysterectomy
Middle Aged
Mitotic Index
Ovariectomy
Rectal Neoplasms / complications*
Rectal Neoplasms / pathology*
Reoperation
Tomography, X-Ray Computed
Vaginal Neoplasms / complications*
Vaginal Neoplasms / pathology*

Substances

Androgens