Abstract
We report a case of concomitant mantle cell lymphoma (MCL) and multiple myeloma (MM) in which we investigated the possibility of a clonal relationship. A 76-year-old man was diagnosed with MCL [immunoglobulin (Ig)M,D-kappa; stage IVB] and MM (IgG-kappa; stage I). Ig heavy chain (IgH) gene complementarity-determining region 3 in DNA from both the MCL tumor and from single MM cells from bone marrow smears was amplified to investigate whether there was a clonal relationship between MCL and MM. Sequence analysis revealed no clonal relationship between MCL and MM in our patient.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Bone Marrow / pathology
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Chromosomes, Human, Pair 11 / genetics
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Chromosomes, Human, Pair 11 / ultrastructure
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Chromosomes, Human, Pair 14 / genetics
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Chromosomes, Human, Pair 14 / ultrastructure
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Clone Cells / chemistry
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Clone Cells / pathology
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DNA, Neoplasm / analysis
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Genes, Immunoglobulin
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Humans
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Ileal Neoplasms / genetics
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Ileal Neoplasms / pathology*
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Ileocecal Valve / pathology*
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Immunoglobulin G / genetics
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Immunoglobulin Heavy Chains / genetics
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Immunoglobulin kappa-Chains / genetics
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Lymphoma, Mantle-Cell / genetics
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Lymphoma, Mantle-Cell / pathology*
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Male
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Multiple Myeloma / genetics
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Multiple Myeloma / pathology*
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Myeloma Proteins / genetics
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Neoplasm Proteins / genetics
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Neoplasms, Multiple Primary / genetics
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Neoplasms, Multiple Primary / pathology*
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Neoplastic Stem Cells / chemistry
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Neoplastic Stem Cells / pathology*
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Polymerase Chain Reaction / methods*
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Translocation, Genetic
Substances
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DNA, Neoplasm
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Immunoglobulin G
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Immunoglobulin Heavy Chains
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Immunoglobulin kappa-Chains
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Myeloma Proteins
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Neoplasm Proteins