Methylenetetrahydrofolate reductase (MTHFR). Incidence of the C677T mutation in a Siberian female population

A V Belkovets; S A Kurilovich; D P Agarwal

Methylenetetrahydrofolate reductase (MTHFR). Incidence of the C677T mutation in a Siberian female population

Anthropol Anz. 2001 Mar;59(1):19-25.

Authors

A V Belkovets¹, S A Kurilovich, D P Agarwal

Affiliation

¹ Institute of Internal Medicine, Novosibirsk, Russia.

PMID: 11360806

Abstract

We have studied the distribution of genotypes of the MTHFR gene among the Siberian female population and compared it with the frequency of this mutation in different populations. The TT genotype and the T allele frequency in 299 women from Novosibirsk (West Siberia) was determined. The presence of the C677T allele was determined by PCR and Hinf I digestion. The homozygous genotype TT was detected in 8.69% of the population sample. The frequency of the C677T mutant allele was found to be 0.290.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Arteriosclerosis / genetics
Female
Gene Frequency / genetics
Genetic Predisposition to Disease / genetics
Genetics, Population*
Genotype
Humans
Hyperhomocysteinemia / genetics
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation / genetics*
Oxidoreductases Acting on CH-NH Group Donors / genetics*
Polymorphism, Genetic / genetics
Siberia

Substances

Oxidoreductases Acting on CH-NH Group Donors
Methylenetetrahydrofolate Reductase (NADPH2)