The genetics of signal transduction and the effect of smoking on intrauterine growth

E Bottini; F Gloria-Bottini; M La Torre; N Lucarini

doi:10.1093/ije/30.2.400

The genetics of signal transduction and the effect of smoking on intrauterine growth

Int J Epidemiol. 2001 Apr;30(2):400-2. doi: 10.1093/ije/30.2.400.

Authors

E Bottini¹, F Gloria-Bottini, M La Torre, N Lucarini

Affiliation

¹ Chair of Preventive and Social Pediatrics, University of Rome, Tor Vergata, School of Medicine, Rome, Italy. bottini@med.uniroma2.it

PMID: 11369750
DOI: 10.1093/ije/30.2.400

Abstract

We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples point to a protective role of maternal ACP1 genotypes with medium-high activity against intrauterine growth retardation caused by smoking.

Publication types

Multicenter Study

MeSH terms

Analysis of Variance
Birth Weight
Case-Control Studies
Female
Fetal Growth Retardation / chemically induced*
Fetal Growth Retardation / epidemiology
Genotype
Humans
Infant, Newborn
Isoenzymes / genetics*
Italy / epidemiology
Pregnancy / genetics*
Pregnancy in Diabetics / genetics
Protein Tyrosine Phosphatases / genetics*
Proto-Oncogene Proteins*
Signal Transduction / genetics*
Smoking / adverse effects*
Smoking / genetics*

Substances

Isoenzymes
Proto-Oncogene Proteins
ACP1 protein, human
Protein Tyrosine Phosphatases