Abstract
We studied the expression of the apoptosis-related protein, E2F-1, in Down's syndrome (DS) brains. The immunoreactivity for E2F-1 was detected in the pyramidal neurons of the cerebral cortex from DS brains exhibiting the neuropathological features of dementia of Alzheimer type (DAT), in accordance with the amyloid beta protein (A beta) deposition in the neuron. Therefore, the implication is that A beta deposition may trigger E2F-1-mediated neuronal apoptosis in DS brains with DAT.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Alzheimer Disease / etiology
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Alzheimer Disease / metabolism*
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Alzheimer Disease / pathology
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Amyloid beta-Peptides / metabolism
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Apoptosis / genetics
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Cell Cycle Proteins*
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Cerebral Cortex / metabolism
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Cerebral Cortex / pathology
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Child
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Child, Preschool
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DNA-Binding Proteins*
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Down Syndrome / complications
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Down Syndrome / metabolism*
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Down Syndrome / pathology
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E2F Transcription Factors
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E2F1 Transcription Factor
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Fetus
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Humans
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Immunohistochemistry
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Infant
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Infant, Newborn
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Microtubule-Associated Proteins / metabolism
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Middle Aged
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Plaque, Amyloid / metabolism
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Plaque, Amyloid / pathology
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Pyramidal Cells / metabolism
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Pyramidal Cells / pathology
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Transcription Factors / metabolism*
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Tumor Suppressor Protein p53 / metabolism
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Up-Regulation / genetics*
Substances
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Amyloid beta-Peptides
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Cell Cycle Proteins
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DNA-Binding Proteins
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E2F Transcription Factors
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E2F1 Transcription Factor
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E2F1 protein, human
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Microtubule-Associated Proteins
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Transcription Factors
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Tumor Suppressor Protein p53