Abstract
New insight has recently been obtained into the molecular mechanisms regulating the function of lymphatic endothelial cells. Vascular endothelial growth factors-C and -D have been shown to stimulate lymphangiogenesis, and their receptor VEGFR-3 has been linked to human hereditary lymphoedema, although there is evidence that other genes are also involved. These data suggest that it may become possible to stimulate lymphatic growth and function and to treat tissue oedema involved in many diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Membrane Permeability
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Chromosomes, Human, Pair 16 / genetics
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Chromosomes, Human, Pair 5 / genetics
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology
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Endothelial Growth Factors / genetics
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Endothelial Growth Factors / physiology
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Endothelium / cytology
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Endothelium / metabolism
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Eyelashes / abnormalities
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Forecasting
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Forkhead Transcription Factors
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Gene Expression Regulation, Developmental
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Genetic Heterogeneity
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Genetic Linkage
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Humans
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Lymphatic System / cytology
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Lymphatic System / embryology
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Lymphatic System / growth & development
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Lymphatic System / physiology*
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Lymphedema / genetics
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Lymphedema / physiopathology*
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Lymphedema / therapy
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Mice
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Mice, Mutant Strains
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Receptor Protein-Tyrosine Kinases / physiology
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Receptors, Growth Factor / physiology
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Transcription Factors / genetics
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Transcription Factors / physiology
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Turner Syndrome / genetics
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Vascular Endothelial Growth Factor C
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Vascular Endothelial Growth Factor D
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Vascular Endothelial Growth Factor Receptor-3
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X Chromosome / genetics
Substances
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DNA-Binding Proteins
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Endothelial Growth Factors
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Forkhead Transcription Factors
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Receptors, Growth Factor
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Transcription Factors
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Vascular Endothelial Growth Factor C
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Vascular Endothelial Growth Factor D
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mesenchyme fork head 1 protein
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Receptor Protein-Tyrosine Kinases
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Vascular Endothelial Growth Factor Receptor-3