Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

S Tejpar; C Li; C Yu; R Poon; H Denys; R Sciot; E Van Cutsem; J J Cassiman; B A Alman

doi:10.1054/bjoc.2001.1857

Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

Br J Cancer. 2001 Jul 6;85(1):98-101. doi: 10.1054/bjoc.2001.1857.

Authors

S Tejpar¹, C Li, C Yu, R Poon, H Denys, R Sciot, E Van Cutsem, J J Cassiman, B A Alman

Affiliation

¹ The Program in Developmental Biology, The Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada

Abstract

Aggressive fibromatosis harbours mutations resulting in beta-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by beta-catenin stabilization in a human neoplastic process.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytoskeletal Proteins / genetics
Cytoskeletal Proteins / metabolism
Cytoskeletal Proteins / physiology*
Fibromatosis, Aggressive / genetics*
Fibromatosis, Aggressive / metabolism*
HMGB Proteins*
Humans
Precipitin Tests
TCF Transcription Factors
Trans-Activators*
Transcription Factor 7-Like 1 Protein
Transcription Factors / biosynthesis*
Transcription Factors / metabolism
Transcriptional Activation / physiology*
Tumor Cells, Cultured
beta Catenin

Substances

CTNNB1 protein, human
Cytoskeletal Proteins
HMGB Proteins
TCF Transcription Factors
TCF7L1 protein, human
Trans-Activators
Transcription Factor 7-Like 1 Protein
Transcription Factors
beta Catenin