Abstract
The integrin alphavbeta6 is a fibronectin receptor whose expression is not detectable on normal oral epithelium but is increased significantly in healing and in oral epithelial dysplasia and oral squamous cell carcinoma, suggesting it may promote changes associated with tumor development. To study whether alphavbeta6 may drive invasive behavior we have used transfection and retroviral infection to create a panel of epithelial cell lines expressing various levels of alphavbeta6. We report that increased expression of alphavbeta6 in malignant keratinocytes promotes invasion and leads to an increased capacity for migration towards fibronectin. alphavbeta6 expression may have a significant role in contributing to the malignant behavior of epithelial cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Neoplasm*
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Biocompatible Materials
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Carcinoma, Squamous Cell / pathology*
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Carcinoma, Squamous Cell / physiopathology*
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Cell Adhesion / physiology
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Cell Division / physiology
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Cell Movement / drug effects
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Cell Movement / physiology*
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Collagen
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Drug Combinations
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Fibronectins / metabolism
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Fibronectins / pharmacology
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Focal Adhesions / chemistry
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Gene Expression Regulation, Neoplastic
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Humans
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Integrins / analysis
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Integrins / genetics*
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Integrins / metabolism
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Keratinocytes / metabolism
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Keratinocytes / pathology
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Laminin
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Mouth Neoplasms / pathology
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Mouth Neoplasms / physiopathology
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Neoplasm Invasiveness / pathology
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Neoplasm Invasiveness / physiopathology
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Plastics
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Proteoglycans
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Receptors, Fibronectin / analysis
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Receptors, Fibronectin / metabolism
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Retroviridae / genetics
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Skin Neoplasms / pathology*
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Skin Neoplasms / physiopathology*
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Transfection
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Tumor Cells, Cultured
Substances
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Antigens, Neoplasm
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Biocompatible Materials
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Drug Combinations
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Fibronectins
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Integrins
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Laminin
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Plastics
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Proteoglycans
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Receptors, Fibronectin
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integrin alphavbeta6
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matrigel
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Collagen