Abstract
Production of the C-X-C chemokines interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-alpha) in macrophages is stimulated by exposure to human immunodeficiency virus type 1 (HIV-1). We have demonstrated previously that GRO-alpha then stimulates HIV-1 replication in both T lymphocytes and macrophages. Here we demonstrate that IL-8 also stimulates HIV-1 replication in macrophages and T lymphocytes. We further show that increased levels of IL-8 are present in the lymphoid tissue of patients with AIDS. In addition, we demonstrate that compounds which inhibit the actions of IL-8 and GRO-alpha via their receptors, CXCR1 and CXCR2, also inhibit HIV-1 replication in both T lymphocytes and macrophages, indicating potential therapeutic uses for these compounds in HIV-1 infection and AIDS.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / immunology
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Acquired Immunodeficiency Syndrome / virology*
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Antibodies / immunology
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Chemokine CXCL1
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Chemokines, CXC*
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Chemotactic Factors / antagonists & inhibitors
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Chemotactic Factors / pharmacology
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Growth Substances / pharmacology
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HIV-1 / drug effects*
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HIV-1 / physiology
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Humans
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Intercellular Signaling Peptides and Proteins*
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Interleukin-8 / antagonists & inhibitors
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Interleukin-8 / immunology
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Interleukin-8 / metabolism
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Interleukin-8 / pharmacology*
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Lymphoid Tissue / immunology
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Lymphoid Tissue / metabolism
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Macrophages / virology*
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Monocytes
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Phenylurea Compounds / pharmacology
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Receptors, Interleukin-8A / immunology
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Receptors, Interleukin-8B / immunology
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T-Lymphocytes / virology*
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Virus Replication / drug effects
Substances
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Antibodies
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CXCL1 protein, human
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Chemokine CXCL1
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Chemokines, CXC
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Chemotactic Factors
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Growth Substances
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Intercellular Signaling Peptides and Proteins
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Interleukin-8
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Phenylurea Compounds
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Receptors, Interleukin-8A
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Receptors, Interleukin-8B
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SB 225002