Abstract
Pseudomonas aeruginosa is a significant threat to human health as it is frequently recalcitrant to conventional antibacterial therapy. This ubiquitous gram-negative bacterium is notorious for its nutritional and ecological flexibility and its resistance to both antibiotic treatments and sanitary measures. These properties contribute to its prominence as a leading source of opportunistic nosocomial (hospital acquired) and a less appreciated, but significant cause of community acquired infections. P. aeruginosa remains a considerable problem for patients with burns, neutropenic individuals, and cystic fibrosis patients (CF). In this review, we will address the current issues in P. aeruginosa infections in CF. A major emphasis will be placed on the factors predisposing CF patients to colonization with P. aeruginosa.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bacterial Adhesion
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Biofilms / growth & development
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Cystic Fibrosis / complications*
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Cystic Fibrosis / metabolism
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Cystic Fibrosis / microbiology
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Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
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Disease Models, Animal
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Humans
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Inflammation / immunology
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Mice
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Nitric Oxide Synthase / biosynthesis
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Nitric Oxide Synthase Type II
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Pseudomonas Infections / complications
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Pseudomonas Infections / metabolism
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Pseudomonas Infections / microbiology*
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Pseudomonas aeruginosa / pathogenicity*
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Pseudomonas aeruginosa / physiology
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Respiratory Mucosa / enzymology
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Respiratory Mucosa / microbiology
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Respiratory Tract Infections / complications
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Respiratory Tract Infections / metabolism
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Respiratory Tract Infections / microbiology*
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Sialyltransferases / metabolism
Substances
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CFTR protein, human
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Cystic Fibrosis Transmembrane Conductance Regulator
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NOS2 protein, human
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse
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Sialyltransferases