Abstract
The aim of this study was to investigate whether there is an association between overexpression of cyclin D1 and response to therapy. Immunohistochemical overexpression of cyclin D1 was determined in paraffin-embedded specimens from diagnostic biopsies of 89 primary cases of squamous cell carcinoma of the head and neck (SCCHN), using a polyclonal antiserum. The tumor response rates were estimated after curative treatment (i.e. surgery and/or radiotherapy and/or chemotherapy). Patients whose tumors were overexpressing cyclin D1 showed complete or partial response to neoadjuvant chemotherapy with cisplatin/5-FU. In addition, a majority of cyclin D1 negative tumors did not respond at all to this treatment (p = 0.02, Fisher's exact test). This study indicates that immunohistochemical assessment of cyclin D1 expression in SCCHN could be a new predictive marker to select a subgroup of patients that will benefit from neoadjuvant chemotherapy.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / pharmacology*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / biosynthesis*
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Biomarkers, Tumor / genetics
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / metabolism
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / radiotherapy
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Carcinoma, Squamous Cell / surgery
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Chemotherapy, Adjuvant*
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Cisplatin / administration & dosage
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Cobalt Radioisotopes / therapeutic use
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Combined Modality Therapy
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Cyclin D1 / biosynthesis*
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Cyclin D1 / genetics
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Fluorouracil / administration & dosage
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Gene Expression Regulation, Neoplastic / drug effects*
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Gene Expression Regulation, Neoplastic / radiation effects
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Head and Neck Neoplasms / drug therapy*
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Head and Neck Neoplasms / genetics
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Head and Neck Neoplasms / metabolism
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Head and Neck Neoplasms / mortality
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Head and Neck Neoplasms / radiotherapy
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Head and Neck Neoplasms / surgery
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Humans
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Life Tables
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Neoadjuvant Therapy*
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Particle Accelerators
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Radioisotope Teletherapy
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Radiotherapy, Adjuvant
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Radiotherapy, High-Energy
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Remission Induction
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Survival Analysis
Substances
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Biomarkers, Tumor
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Cobalt Radioisotopes
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Neoplasm Proteins
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Cyclin D1
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Cisplatin
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Fluorouracil