Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1

Mutat Res. 2001 Sep 1:480-481:299-304. doi: 10.1016/s0027-5107(01)00189-0.

Abstract

The study of green tea polyphenols as a cancer preventative is approaching a new era, with significant results accumulating rapidly. This paper briefly reviews four topics related to mechanisms of action of tea polyphenols: (I) identification of the genes commonly affected by EGCG, as demonstrated by Clontech's Atlas cDNA Expression Array; (II) the significance of heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) as a new biomarker for early detection of lung cancer, and inhibition of its expression by EGCG; (III) the synergistic or additive effects of EGCG with the cancer preventive agents, sulindac and tamoxifen, on induction of apoptosis in PC-9 cells and on inhibition of intestinal tumor development in multiple intestinal neoplasia (Min) mice; (IV) the results of a 10 year prospective cohort study demonstrating the effectiveness of daily consumption of green tea in preventing cancer, and a prototype study for developing green tea beverage as cancer preventive.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / administration & dosage*
  • Anticarcinogenic Agents / chemistry
  • Biomarkers, Tumor / analysis*
  • Carcinoma, Squamous Cell / chemistry
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / prevention & control*
  • Catechin / administration & dosage
  • Catechin / analogs & derivatives
  • Catechin / chemistry
  • Chemoprevention
  • Cohort Studies
  • Drug Synergism
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic / drug effects
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B*
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Humans
  • Intestinal Neoplasms / chemistry
  • Intestinal Neoplasms / diagnosis
  • Intestinal Neoplasms / genetics
  • Intestinal Neoplasms / prevention & control*
  • Japan
  • Lung Neoplasms / chemistry
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / genetics
  • Lung Neoplasms / prevention & control*
  • Male
  • Mice
  • Mice, Mutant Strains
  • Okadaic Acid / pharmacology
  • Oligonucleotide Array Sequence Analysis
  • Prospective Studies
  • Ribonucleoproteins / analysis*
  • Sulindac / administration & dosage*
  • Tea* / chemistry
  • Tumor Cells, Cultured

Substances

  • Anticarcinogenic Agents
  • Biomarkers, Tumor
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Ribonucleoproteins
  • Tea
  • hnRNP A2
  • Sulindac
  • Okadaic Acid
  • Catechin
  • epigallocatechin gallate