Abstract
The study of green tea polyphenols as a cancer preventative is approaching a new era, with significant results accumulating rapidly. This paper briefly reviews four topics related to mechanisms of action of tea polyphenols: (I) identification of the genes commonly affected by EGCG, as demonstrated by Clontech's Atlas cDNA Expression Array; (II) the significance of heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) as a new biomarker for early detection of lung cancer, and inhibition of its expression by EGCG; (III) the synergistic or additive effects of EGCG with the cancer preventive agents, sulindac and tamoxifen, on induction of apoptosis in PC-9 cells and on inhibition of intestinal tumor development in multiple intestinal neoplasia (Min) mice; (IV) the results of a 10 year prospective cohort study demonstrating the effectiveness of daily consumption of green tea in preventing cancer, and a prototype study for developing green tea beverage as cancer preventive.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anticarcinogenic Agents / administration & dosage*
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Anticarcinogenic Agents / chemistry
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Biomarkers, Tumor / analysis*
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Carcinoma, Squamous Cell / chemistry
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Carcinoma, Squamous Cell / diagnosis
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Carcinoma, Squamous Cell / prevention & control*
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Catechin / administration & dosage
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Catechin / analogs & derivatives
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Catechin / chemistry
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Chemoprevention
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Cohort Studies
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Drug Synergism
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Female
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic / drug effects
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Heterogeneous-Nuclear Ribonucleoprotein Group A-B*
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Heterogeneous-Nuclear Ribonucleoproteins
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Humans
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Intestinal Neoplasms / chemistry
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Intestinal Neoplasms / diagnosis
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Intestinal Neoplasms / genetics
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Intestinal Neoplasms / prevention & control*
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Japan
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Lung Neoplasms / chemistry
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Lung Neoplasms / diagnosis
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Lung Neoplasms / genetics
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Lung Neoplasms / prevention & control*
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Male
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Mice
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Mice, Mutant Strains
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Okadaic Acid / pharmacology
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Oligonucleotide Array Sequence Analysis
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Prospective Studies
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Ribonucleoproteins / analysis*
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Sulindac / administration & dosage*
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Tea* / chemistry
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Tumor Cells, Cultured
Substances
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Anticarcinogenic Agents
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Biomarkers, Tumor
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Heterogeneous-Nuclear Ribonucleoprotein Group A-B
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Heterogeneous-Nuclear Ribonucleoproteins
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Ribonucleoproteins
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Tea
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hnRNP A2
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Sulindac
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Okadaic Acid
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Catechin
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epigallocatechin gallate