Abstract
Persons co-infected with HTLV-1 and HIV are at increased risk for neurologic disease. These patients may develop HAM/TSP and/or HIV-associated dementia. In this study, we localized cells infected with retrovirus in the central nervous system (CNS) of a patient with both HAM/TSP and HIV-associated dementia. HTLV-1 was localized to astrocytes and HIV to macrophage/microglia. There was no co-infection of a single cell phenotype in this patient. These data suggest that mechanisms other than co-infection of the same CNS cell may play a role in the development of neurologic disease in patients dual infected with HTLV-1 and HIV.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Dementia Complex / complications
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AIDS Dementia Complex / pathology
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AIDS Dementia Complex / virology*
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Adult
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Astrocytes / pathology
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Astrocytes / virology
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Brain / pathology
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Brain / virology
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Central Nervous System / pathology
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Central Nervous System / virology*
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DNA, Viral / analysis
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Fatal Outcome
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Gene Products, tax / genetics
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HIV / genetics
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HIV / isolation & purification
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Human T-lymphotropic virus 1 / genetics
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Human T-lymphotropic virus 1 / isolation & purification
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Humans
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Immunohistochemistry
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In Situ Hybridization
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Macrophages / pathology
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Macrophages / virology
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Male
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Microglia / pathology
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Microglia / virology
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Paraparesis, Tropical Spastic / complications
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Paraparesis, Tropical Spastic / pathology
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Paraparesis, Tropical Spastic / virology*
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Polymerase Chain Reaction
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RNA, Viral / analysis
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Retroviridae / genetics
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Retroviridae / isolation & purification*
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Sarcoma, Kaposi / complications
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Sarcoma, Kaposi / diagnosis
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Spinal Cord / pathology
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Spinal Cord / virology
Substances
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DNA, Viral
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Gene Products, tax
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RNA, Viral