Abstract
A large number of diverse functions have been attributed to the BRCA1 and BRCA2 breast cancer susceptibility genes. Here we review recent progress in the field.
MeSH terms
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BRCA1 Protein / physiology*
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BRCA2 Protein / physiology*
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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DNA / metabolism
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DNA Repair
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DNA-Binding Proteins*
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Fanconi Anemia / genetics
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Fanconi Anemia / physiopathology
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Fanconi Anemia Complementation Group Proteins
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Female
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Genes, BRCA1*
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Genes, BRCA2*
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Humans
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Protein Structure, Tertiary
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RNA Helicases / metabolism
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Transcription, Genetic
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Tumor Suppressor Proteins*
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Ubiquitin-Protein Ligases*
Substances
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BRCA1 Protein
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BRCA2 Protein
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Carrier Proteins
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DNA-Binding Proteins
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Fanconi Anemia Complementation Group Proteins
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Nuclear Proteins
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Tumor Suppressor Proteins
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DNA
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BARD1 protein, human
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Ubiquitin-Protein Ligases
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BRIP1 protein, human
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RNA Helicases