Abstract
Several methods to model human Ph+ leukemia in laboratory mice are available, including propagation of BCR/ABL-expressing cells in mice, xenotransplantation of primary Ph+ leukemia cells into immunodeficient mice, BCR/ABL transgenic mice, and BCR/ABL retroviral bone marrow transduction and transplantation. Recent studies in these different model systems have yielded important advances in our knowledge of the pathogenesis and therapy of human chronic myeloid leukemia and Ph+ B-lymphoblastic leukemia, and are the subject of this review.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bone Marrow Transplantation
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Disease Models, Animal*
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Fusion Proteins, bcr-abl / genetics
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Fusion Proteins, bcr-abl / metabolism
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Humans
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Leukemia, B-Cell / etiology
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Leukemia, B-Cell / metabolism
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Leukemia, B-Cell / therapy
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / etiology*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
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Mice
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Mice, Transgenic
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
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Retroviridae / genetics
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Transduction, Genetic
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Transplantation, Heterologous
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Tumor Cells, Cultured