Abstract
The KAI1 gene has been identified as a metastasis suppressor gene in human prostate cancer. Decrease or loss of KAI1/CD82 expression has been shown to be associated with poorer prognosis and metastasis in carcinomas of various organs. The purpose of this study was to examine whether KAI1/CD82 is expressed in bone and soft tissue tumors, and whether it is associated with metastasis to the lungs. Immunohistochemically, KAI1/CD82 expression in benign and malignant soft tissue tumors was noted in 83% and 37% of cases, respectively. KAI1/CD82 was- also expressed in benign bone tumors and osteosarcomas in 67% and 36% of the cases, respectively. Four (40%) of 10 osteosarcoma cases with no lung metastasis and one (25%) of four osteosarcoma cases with lung metastasis were positive for KAI1/CD82, respectively. Metastasis of osteosarcoma cells to the lungs was not correlated with the loss of KAI1/CD82 in osteosarcoma cells.
MeSH terms
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Adolescent
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Adult
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Aged
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Antigens, CD*
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Antigens, Surface / analysis
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Antigens, Surface / metabolism*
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Blotting, Western
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Bone Neoplasms / chemistry
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Bone Neoplasms / metabolism*
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Bone Neoplasms / pathology
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Child
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Child, Preschool
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Humans
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Immunoenzyme Techniques
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In Situ Hybridization
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Infant
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Kangai-1 Protein
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Lung Neoplasms / chemistry
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Lung Neoplasms / metabolism*
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Lung Neoplasms / secondary
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Membrane Glycoproteins / analysis
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Middle Aged
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Neoplasm Metastasis
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Oligonucleotide Probes / chemistry
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Proto-Oncogene Proteins*
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RNA, Messenger / metabolism
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RNA, Neoplasm / analysis
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Soft Tissue Neoplasms / chemistry
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Soft Tissue Neoplasms / metabolism*
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Soft Tissue Neoplasms / pathology
Substances
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Antigens, CD
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Antigens, Surface
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CD82 protein, human
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Kangai-1 Protein
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Membrane Glycoproteins
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Oligonucleotide Probes
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Proto-Oncogene Proteins
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RNA, Messenger
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RNA, Neoplasm