Abstract
A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Chromosomes, Human, Pair 1
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Chromosomes, Human, Pair 10
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Chromosomes, Human, Pair 16
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Chromosomes, Human, Pair 9
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Dopamine beta-Hydroxylase / genetics
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Dystonia Musculorum Deformans / genetics
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Genetic Linkage / genetics
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Genetic Markers / genetics
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Genetic Testing*
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Genome*
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Humans
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Male
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Middle Aged
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Parkinson Disease / diagnosis
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Parkinson Disease / genetics*
Substances
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Genetic Markers
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Dopamine beta-Hydroxylase