Abstract
The monoclonal antibody, mAb35, which binds the main immunogenic region of the post-junctional muscle receptor for acetylcholine (AChR), results in contractile dysfunction and symptoms of experimental myasthenia gravis (EAMG). As described below, exposure to mAb35 also results in the production by muscle of increased levels of the interferon-gamma (IFN-gamma)-activating cytokine, interleukin-15. This effect is accompanied by the increased trafficking of leukocytes through muscle, some that produce IFN-gamma. These observations may be relevant to the induction of disease symptoms since numerous reports from other investigators indicate that IFN-gamma may play a pivotal role in this disease process.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adoptive Transfer
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Amino Acid Sequence
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Animals
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Antibodies, Monoclonal / pharmacology
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / immunology
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Female
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Interferon-gamma / immunology*
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Interferon-gamma / metabolism
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Interleukin-15 / immunology*
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Interleukin-15 / metabolism
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Lymph Nodes / cytology
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Macrophages / cytology
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Macrophages / immunology
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Molecular Sequence Data
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Muscle Fibers, Skeletal / immunology*
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Muscle Fibers, Skeletal / metabolism
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Muscle, Skeletal / cytology
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Muscle, Skeletal / immunology
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Myasthenia Gravis, Autoimmune, Experimental / immunology*
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Myasthenia Gravis, Autoimmune, Experimental / metabolism
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Rats
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Rats, Inbred Lew
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Receptors, Cholinergic / chemistry
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Receptors, Cholinergic / immunology*
Substances
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Antibodies, Monoclonal
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Interleukin-15
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Receptors, Cholinergic
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Interferon-gamma