Objective: To analyze the frequency of beta-fibrinogen (beta-FBG) gene G/A-455 polymorphisms in Guangdong Chinese population and the relationship between genotype and plasma fibrinogen levels.
Methods: DNA of 210 samples were analyzed by using PCR-RFLP. Turbidimetric method for the levels of plasma fibrinogen was performed in 92 samples.
Results: The frequency of beta-FBG G/A-455 genotype A/A was 0.038; G/G was 0.514 and G/A was 0.448. The frequency of the A-allele was 0.262. The average plasma fibrinogen level in 46 samples of genotype G/A was (2.18 +/- 0.24) g/L and in 42 samples of G/G genotype was (2.03 +/- 0.25) g/L. There was significant difference between genotype and plasma fibrinogen (P < 0.01).
Conclusion: The frequency of beta-FBG G/A-455 A-allele in Guangdong Chinese population is higher than that in European. The plasma fibrinogen level in G/A genotype is higher than that in G/G genotype. It suggested that the beta-FBG gene expression might be associated with the genotype.