[Connection of HindIII-polymorphism in the lipoprotein lipase gene with myocardial infarct and life span in elderly ischemic heart disease patients]

Mol Biol (Mosk). 2001 Sep-Oct;35(5):787-91.
[Article in Russian]

Abstract

Allele and genotype frequencies of the HindIII polymorphism of the lipoprotein lipase (LPL) gene were studied in patients with myocardial infarction (MI) and stable angina of effort (SAE), including long-lived people (over 90). The polymorphism proved to be associated with MI and with the life span, genotype H+/H+ being predisposing to MI and allele H- being protective. The allele and genotype frequencies of long-lived people differed significantly from the Hardy-Weinberg proportions and from those of SAE patients aged up to 90. An excess of heterozygotes in this group suggests a selective pressure which eliminates homozygotes. Possibly, heterozygotes H+/H- have an adaptive advantage, which provides for their longevity.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Base Sequence
  • DNA Primers
  • Genotype
  • Humans
  • Life Expectancy
  • Lipoprotein Lipase / genetics*
  • Myocardial Infarction / enzymology
  • Myocardial Infarction / genetics*
  • Myocardial Ischemia / enzymology
  • Myocardial Ischemia / genetics*
  • Polymorphism, Genetic*
  • Site-Specific DNA-Methyltransferase (Adenine-Specific) / genetics*

Substances

  • DNA Primers
  • DNA modification methylase HindIII
  • Site-Specific DNA-Methyltransferase (Adenine-Specific)
  • Lipoprotein Lipase