Abstract
In this study we examined well fixed brain biopsies of 9 sporadic CJD, 9 iatrogenic CJD cases, 2 hereditary CJD (Gly200Lys and Val203Iso), a case of vCJD and a case of fatal familial insomnia (FFI) from a new French family collected over the years at the Service de Neuropathologie, Hopital Neurologique, Lyon, France. Tubulovesicular structures (TVS) were found in every case including FFI and nvCJD. Thus, TVS, as we suggested previously are important pathologic structure which significance should be more extensively studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Amyloid / analysis
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Amyloid / genetics
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Biopsy
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Cerebral Cortex / chemistry
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Cerebral Cortex / ultrastructure*
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Codon / genetics
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Creutzfeldt-Jakob Syndrome / pathology*
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Creutzfeldt-Jakob Syndrome / transmission
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France
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Human Growth Hormone / adverse effects
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Humans
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Iatrogenic Disease
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Microscopy, Electron
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Point Mutation
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Prion Diseases / genetics
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Prion Diseases / pathology*
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Prion Proteins
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Prions
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Protein Precursors / analysis
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Protein Precursors / genetics
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Vacuoles / ultrastructure
Substances
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Amyloid
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Codon
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PRNP protein, human
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Prion Proteins
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Prions
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Protein Precursors
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Human Growth Hormone