Hodgkin's lymphoma of T-cell type: clonal association with a CD30+ cutaneous lymphoma

Hum Pathol. 2001 Nov;32(11):1269-72. doi: 10.1053/hupa.2001.28963.

Abstract

The derivation of Reed-Sternberg cells in Hodgkin's lymphoma has been a subject of great interest. In most cases, Reed-Sternberg cells seem to be derived from germinal center B cells. In few sporadic cases, a T-cell origin has been shown. This article supports the concept of a T-cell derivation for rare cases of Hodgkin's lymphoma and provides evidence of a novel mechanism of pathogenesis from chronic inflammation in the skin.

Publication types

  • Case Reports

MeSH terms

  • Base Sequence
  • Clone Cells
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
  • Hodgkin Disease / complications*
  • Hodgkin Disease / genetics*
  • Hodgkin Disease / pathology
  • Humans
  • Immunohistochemistry
  • Ki-1 Antigen / analysis*
  • Ki-1 Antigen / immunology
  • Lymph Nodes / pathology
  • Lymphoma, T-Cell / chemistry
  • Lymphoma, T-Cell / complications*
  • Lymphoma, T-Cell / genetics
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymorphism, Single-Stranded Conformational
  • Reed-Sternberg Cells / chemistry*
  • Sequence Homology, Nucleic Acid
  • Skin / pathology
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / complications*
  • Skin Neoplasms / genetics

Substances

  • Ki-1 Antigen