Abstract
It was shown that the 3-month supplementation of patients having colon polyps with folic acid (5 mg/day) led to a 35% decrease in abnormally high ornithine decarboxylase activity in polyps that was accompanied by a 43% increase of S-adenosylmethionine content in polyps.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adenomatous Polyps / enzymology
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Adenomatous Polyps / metabolism*
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Colonic Polyps / enzymology
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Colonic Polyps / metabolism*
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Disease Progression
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Double-Blind Method
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Enzyme Induction / drug effects
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Female
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Folic Acid / administration & dosage
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Folic Acid / pharmacology*
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Gene Expression Regulation, Neoplastic / drug effects
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Humans
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Male
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Ornithine Decarboxylase / biosynthesis*
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Ornithine Decarboxylase / genetics
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S-Adenosylmethionine / metabolism*
Substances
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Neoplasm Proteins
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S-Adenosylmethionine
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Folic Acid
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Ornithine Decarboxylase