Objective: To assess the risk factors of myocardial infarction (MI) and the polymorphism of the gene Apoliprotein (ApoE) genotype among MI patients and their siblings.
Methods: Questionnaire survey and clinical examination were conducted to 65 male MI patients, 141 "healthy" male siblings of the MI patients, and 47 healthy persons matched in age and sex.
Results: (1) The medians of TC, TG, LDL-C, TC/HDL-C in MI group and sibling group were higher than those in the control group with statistical significance. (2) BMI > 25 kg/m(2), cigarette > 10/d, TC > 5.2 mmol/L, TG > 2.26 mmol/L, LDL-C > 3.4 mmol/L, TC/HDL-C > 5.0, and FBG > 5.6 mmol/L were risk factors for MI; and HDL-C > 0.9 mmol/L was a protective factor for MI. (3) Among the three genotypes of ApoE, E3/3 was the commonest one. However, no significant difference was found in the distribution frequencies of these 3 genotypes, levels of serum lipid and lipoprotein, and TC/HDL-C. (4) Among the MI patients the number of allele E4 carrier was nearly twice the number of the non-allele E4 carrier.
Conclusion: Dyslipidemia is an important risk factor for MI, and polymorphism of ApoE may be an indirect risk factor of coronary heart disease genetically.