Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions

Isabelle Widmer; Marion Wernli; Felix Bachmann; Fred Gudat; Gieri Cathomas; Peter Erb

doi:10.1128/jvi.76.5.2551-2556.2002

Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions

J Virol. 2002 Mar;76(5):2551-6. doi: 10.1128/jvi.76.5.2551-2556.2002.

Authors

Isabelle Widmer¹, Marion Wernli, Felix Bachmann, Fred Gudat, Gieri Cathomas, Peter Erb

Affiliation

¹ Institute for Medical Microbiology, University of Basel, Petersplatz 10, CH-4003 Basel, Switzerland.

Abstract

Expression of human herpesvirus 8 viral Bcl-2 protein was demonstrated in spindle cells of late-stage Kaposi's sarcoma lesions but not in primary effusion lymphoma cell lines. In contrast, strong expression of human Bcl-2 was found in stimulated primary effusion lymphoma cells, whereas in Kaposi's sarcoma lesions preferential mononuclear cells, and to a lesser extent spindle cells, stained positive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Herpesvirus 8, Human / genetics*
Herpesvirus 8, Human / metabolism*
Herpesvirus 8, Human / pathogenicity
Humans
Immunohistochemistry
Lymphoma / metabolism*
Proto-Oncogene Proteins c-bcl-2 / metabolism*
Sarcoma / metabolism
Sarcoma / virology
Sarcoma, Kaposi / metabolism*
Sarcoma, Kaposi / virology
Tumor Cells, Cultured

Substances

Proto-Oncogene Proteins c-bcl-2