The role of allele variants of apoB, apoCIII, and apoE genes in genetical predisposition to coronary disease was studied in Kazakhs and Uigurs. A total of 241 coronary patients and 205 healthy controls (all males) were examined. ApoB, apoCIII, and apoE gene polymorphism was studied by the polymerase chain reaction with thermostable Tag DNA polymerase. No significant relationship between the studied genes polymorphism and coronary disease was detected in the Kazakhs and Uigurs.