CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease

J P Wood; K Bieda; M Segni; J Herwig; M Krause; K H Usadel; K Badenhoop

doi:10.1046/j.1365-2370.2002.00262.x

CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease

Eur J Immunogenet. 2002 Feb;29(1):73-4. doi: 10.1046/j.1365-2370.2002.00262.x.

Authors

J P Wood¹, K Bieda, M Segni, J Herwig, M Krause, K H Usadel, K Badenhoop

Affiliation

¹ Medical Department 1, Division of Endocrinology, Centre of Internal Medicine, Johann Wolfgang Goethe University Hospital, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.

PMID: 11841494
DOI: 10.1046/j.1365-2370.2002.00262.x

Abstract

A point mutation in the leukocyte common antigen (CD45, C-->G77, exon 4) was investigated in patients with type 1 diabetes (IDDM), patients with Graves' disease and controls. The distribution did not differ significantly between patients and controls. This CD45 variant does not therefore confer susceptibility to either IDDM or Graves' disease.

MeSH terms

Diabetes Mellitus, Type 1 / genetics*
Exons
Genetic Predisposition to Disease*
Graves Disease / genetics*
Humans
Leukocyte Common Antigens / genetics*
Protein Tyrosine Phosphatase, Non-Receptor Type 1

Substances

Leukocyte Common Antigens
Protein Tyrosine Phosphatase, Non-Receptor Type 1