Abstract
Interleukin-18 (IL-18) bioactivity in sera and IL-18 mRNA expression in leukaemia cells of three patients with adult T-cell leukaemia (ATL), acute mixed lineage leukaemia (AMLL) and acute lymphocytic leukaemia (ALL) accompanied with high serum IL-18 levels have been analysed. There was little serum IL-18 bioactivity in the three patients with ATL, AMLL and ALL, while IL-18 mRNA expression was detected in leukaemia cells of all three patients.
MeSH terms
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Acute Disease
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Aged
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Case-Control Studies
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Dose-Response Relationship, Drug
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Female
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Humans
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Interferon-gamma / biosynthesis
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Interferon-gamma / drug effects
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Interleukin-18 / blood
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Interleukin-18 / genetics
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Interleukin-18 / physiology*
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Leukemia / blood*
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Leukemia / metabolism
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Leukemia-Lymphoma, Adult T-Cell / blood
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Leukemia-Lymphoma, Adult T-Cell / metabolism
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Male
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Middle Aged
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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RNA, Messenger / metabolism*
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Tumor Cells, Cultured / drug effects
Substances
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Interleukin-18
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RNA, Messenger
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Interferon-gamma