Transcription factor complexes

Curr Opin Struct Biol. 2002 Apr;12(2):225-30. doi: 10.1016/s0959-440x(02)00314-7.

Abstract

Considerable progress has been made during the past year on structural studies of the eukaryotic and bacterial transcription factors that control RNA polymerase function via the formation of multiprotein complexes on promoter DNA. Recently determined structures include negative cofactor 2 recognizing a preformed TATA-box-binding protein-DNA binary complex, a dimer of BmrR bound to both DNA and tetra-phenylphosphonium, DNA-bound complexes of SarA and FadR, leukemia-associated AML1-CBFbeta-DNA ternary complexes and a SAP1-SRF-DNA ternary complex.

Publication types

  • Review

MeSH terms

  • Bacteria / genetics
  • Bacterial Proteins*
  • Core Binding Factor Alpha 2 Subunit
  • DNA / chemistry
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Humans
  • Leukemia / genetics
  • Models, Molecular*
  • Phosphoproteins / chemistry
  • Phosphoproteins / metabolism
  • Protein Conformation
  • Protein Kinases / chemistry
  • Protein Kinases / metabolism
  • Proto-Oncogene Proteins*
  • Schizosaccharomyces pombe Proteins*
  • TATA-Box Binding Protein
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism
  • Transcription Factor AP-2
  • Transcription Factors / chemistry*
  • Transcription Factors / metabolism*
  • Transcription, Genetic

Substances

  • Bacterial Proteins
  • BmrR protein, bacteria
  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins
  • Phosphoproteins
  • Proto-Oncogene Proteins
  • RUNX1 protein, human
  • Sap1 protein, S pombe
  • Schizosaccharomyces pombe Proteins
  • TATA-Box Binding Protein
  • Trans-Activators
  • Transcription Factor AP-2
  • Transcription Factors
  • down-regulator of transcription 1
  • DNA
  • Protein Kinases
  • serum response factor kinase